3R66
Crystal structure of human ISG15 in complex with NS1 N-terminal region from influenza virus B, Northeast Structural Genomics Consortium Target IDs HX6481, HR2873, and OR2
Summary for 3R66
Entry DOI | 10.2210/pdb3r66/pdb |
Related | 1XEQ 1Z2M |
Descriptor | Non-structural protein 1, Ubiquitin-like protein ISG15 (3 entities in total) |
Functional Keywords | structural genomics, psi-biology, northeast structural genomics consortium, nesg, innate immunity, isg15 conjugation, viral protein-antiviral protein complex, viral protein/antiviral protein |
Biological source | Influenza B virus More |
Cellular location | Host cytoplasm : P03502 Cytoplasm : P05161 |
Total number of polymer chains | 4 |
Total formula weight | 62471.30 |
Authors | Guan, R.,Ma, L.C.,Krug, R.M.,Montelione, G.T.,Northeast Structural Genomics Consortium (NESG) (deposition date: 2011-03-21, release date: 2011-06-08, Last modification date: 2023-09-13) |
Primary citation | Guan, R.,Ma, L.C.,Leonard, P.G.,Brendan, A.R.,Sridharan, H.,Zhao, C.,Krug, R.M.,Montelione, G.T. The Structure of the complex of ISG15 and Influenza B virus NS1 Protein: implications for the mechanism of SN1-mediated inhibition of ISG15 conjugation To be Published, |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report