3R0I

IspC in complex with an N-methyl-substituted hydroxamic acid

Summary for 3R0I

Entry DOI	10.2210/pdb3r0i/pdb
Related	1K5H 1ONP 1Q0L
Descriptor	1-deoxy-D-xylulose 5-phosphate reductoisomerase, MANGANESE (II) ION, {(1S)-1-(3,4-difluorophenyl)-4-[hydroxy(methyl)amino]-4-oxobutyl}phosphonic acid, ... (4 entities in total)
Functional Keywords	antimalarial agents, inhibitors, ispc, non-mevalonate pathway, rossmann fold, reductoisomerase of desoxy-xylulose-5p to methyl-erythritol-3p, nadph, mn, reverse hydroxamic acid ligand binding, cytosol, oxidoreductase-antibiotic complex, oxidoreductase/antibiotic
Biological source	Escherichia coli K-12
Total number of polymer chains	2
Total formula weight	90403.08
Authors	Behrendt, C.T.,Kunfermann, A.,Illarionova, V.,Matheeussen, A.,Pein, M.K.,Graewert, T.,Bacher, A.,Eisenreich, W.,Illarionov, B.,Fischer, M.,Maes, L.,Groll, M.,Kurz, T. (deposition date: 2011-03-08, release date: 2011-09-07, Last modification date: 2023-09-13)
Primary citation	Behrendt, C.T.,Kunfermann, A.,Illarionova, V.,Matheeussen, A.,Pein, M.K.,Grawert, T.,Kaiser, J.,Bacher, A.,Eisenreich, W.,Illarionov, B.,Fischer, M.,Maes, L.,Groll, M.,Kurz, T. Reverse Fosmidomycin Derivatives against the Antimalarial Drug Target IspC (Dxr). J.Med.Chem., 54:6796-6802, 2011 Cited by PubMed: 21866890 DOI: 10.1021/jm200694q PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation