3QU8

Crystal structure of a human cytochrome P450 2B6 (Y226H/K262R) in complex with the inhibitor 4-(4-Nitrobenzyl)pyridine.

Summary for 3QU8

• Entry DOI: 10.2210/pdb3qu8/pdb
• Related: 3IBD 3QOA
• Descriptor: Cytochrome P450 2B6, PROTOPORPHYRIN IX CONTAINING FE, 4-(4-nitrobenzyl)pyridine, ... (5 entities in total)
• Functional Keywords: p450, cytochrome p450 2b6, monooxygenase, membrane protein, cyp2b6, endoplasmic reticulum, heme, iron, membrane, metal binding, microsome, phosphoprotein, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane; Peripheral membrane protein: P20813
• Total number of polymer chains: 6
• Total formula weight: 336602.63

Authors

Shah, M.B.,Pascual, J.,Stout, C.D.,Halpert, J.R. (deposition date: 2011-02-23, release date: 2011-09-21, Last modification date: 2023-09-13)

• Primary citation: Shah, M.B.,Pascual, J.,Zhang, Q.,Stout, C.D.,Halpert, J.R.; Structures of Cytochrome P450 2B6 Bound to 4-Benzylpyridine and 4-(4-Nitrobenzyl)pyridine: Insight into Inhibitor Binding and Rearrangement of Active Site Side Chains.; Mol.Pharmacol., 80:1047-1055, 2011; PubMed: 21875942; DOI: 10.1124/mol.111.074427

Experimental method

X-RAY DIFFRACTION (2.8 Å)