3QNB

Crystal Structure of an Engineered OXA-10 Variant with Carbapenemase Activity, OXA-10loop24

Summary for 3QNB

• Entry DOI: 10.2210/pdb3qnb/pdb
• Related: 3QNC
• Descriptor: Oxacillinase, SULFATE ION, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: antibiotic resistance, hydrolysis of amide bond of beta-lactam compounds, hydrolase
• Biological source: Escherichia coli; More
• Total number of polymer chains: 4
• Total formula weight: 111608.82

Authors

De Luca, F.,Benvenuti, M.,Carboni, F.,Pozzi, C.,Rossolini, G.M.,Mangani, S.,Docquier, J.D. (deposition date: 2011-02-08, release date: 2011-11-02, Last modification date: 2023-12-06)

• Primary citation: De Luca, F.,Benvenuti, M.,Carboni, F.,Pozzi, C.,Rossolini, G.M.,Mangani, S.,Docquier, J.D.; Evolution to carbapenem-hydrolyzing activity in noncarbapenemase class D {beta}-lactamase OXA-10 by rational protein design.; Proc.Natl.Acad.Sci.USA, 108:18424-18429, 2011; PubMed: 22042844; DOI: 10.1073/pnas.1110530108

Experimental method

X-RAY DIFFRACTION (1.95 Å)