3Q05

An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity

Summary for 3Q05

• Entry DOI: 10.2210/pdb3q05/pdb
• Related: 3Q01 3Q06
• Descriptor: Cellular tumor antigen p53, DNA (26-MER), ZINC ION, ... (5 entities in total)
• Functional Keywords: beta sandwich, multidomain, oligomerization, tp53, p53, tumor suppressor, tetramer, dna binding, antitumor protein-dna complex, antitumor protein/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
• Total number of polymer chains: 6
• Total formula weight: 122710.34

Authors

Petty, T.J.,Halazonetis, T.D. (deposition date: 2010-12-15, release date: 2011-05-11, Last modification date: 2023-09-13)

• Primary citation: Petty, T.J.,Emamzadah, S.,Costantino, L.,Petkova, I.,Stavridi, E.S.,Saven, J.G.,Vauthey, E.,Halazonetis, T.D.; An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.; Embo J., 30:2167-2176, 2011; PubMed: 21522129; DOI: 10.1038/emboj.2011.127

Experimental method

X-RAY DIFFRACTION (2.4 Å)