3PSL

Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3 based peptide mimetic

Summary for 3PSL

Entry DOI	10.2210/pdb3psl/pdb
Descriptor	WD repeat-containing protein 5, N-alpha acetylated form of histone H3 (3 entities in total)
Functional Keywords	chromatin, histone, beta-propeller, scaffolding, rbbp5, mll1, nucleus, transcription - transcription inhibitor complex, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: P61964
Total number of polymer chains	4
Total formula weight	70850.37
Authors	Avdic, V.,Zhang, P.,Lanouette, S.,Voronova, A.,Skerjanc, I.,Couture, J.-F. (deposition date: 2010-12-01, release date: 2010-12-22, Last modification date: 2023-09-06)
Primary citation	Avdic, V.,Zhang, P.,Lanouette, S.,Voronova, A.,Skerjanc, I.,Couture, J.F. Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3-based peptide mimetic. Faseb J., 25:960-967, 2011 Cited by PubMed: 21135039 DOI: 10.1096/fj.10-171959 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation