3PO7

Human monoamine oxidase B in complex with zonisamide

Summary for 3PO7

Entry DOI	10.2210/pdb3po7/pdb
Descriptor	Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, 1-(1,2-benzoxazol-3-yl)methanesulfonamide, ... (4 entities in total)
Functional Keywords	flavin-binding amine oxidase, neurotransmitter metabolism, fad, mitochondrial outer membrane, antiparkinson drug, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side: P27338
Total number of polymer chains	2
Total formula weight	119671.01
Authors	Binda, C.,Aldeco, M.,Mattevi, A.,Edmondson, D.E. (deposition date: 2010-11-22, release date: 2011-01-12, Last modification date: 2023-11-01)
Primary citation	Binda, C.,Aldeco, M.,Mattevi, A.,Edmondson, D.E. Interactions of monoamine oxidases with the antiepileptic drug zonisamide: specificity of inhibition and structure of the human monoamine oxidase B complex J.Med.Chem., 54:909-912, 2011 Cited by PubMed: 21175212 DOI: 10.1021/jm101359c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation