3PO1

Thrombin in complex with Benzothiazole Guanidine

Summary for 3PO1

• Entry DOI: 10.2210/pdb3po1/pdb
• Descriptor: Thrombin light chain, Thrombin heavy chain, thrombin peptide, ... (8 entities in total)
• Functional Keywords: serine protease, coagulation factor ii, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734 P00734
• Total number of polymer chains: 4
• Total formula weight: 33563.35

Authors

Xue, Y. (deposition date: 2010-11-21, release date: 2011-11-23, Last modification date: 2012-07-25)

• Primary citation: Karle, M.,Knecht, W.,Xue, Y.; Discovery of benzothiazole guanidines as novel inhibitors of thrombin and trypsin IV.; Bioorg.Med.Chem.Lett., 22:4839-4843, 2012; PubMed: 22726924; DOI: 10.1016/j.bmcl.2012.05.046

Experimental method

X-RAY DIFFRACTION (1.65 Å)