3PLZ

Human LRH1 LBD bound to GR470

Summary for 3PLZ

• Entry DOI: 10.2210/pdb3plz/pdb
• Related: 1YOK
• Descriptor: FTZ-F1 related protein, Nuclear receptor coactivator 2, (3aS,6aR)-5-[(4E)-oct-4-en-4-yl]-N,4-diphenyl-2,3,6,6a-tetrahydropentalen-3a(1H)-amine, ... (5 entities in total)
• Functional Keywords: alpha helical sandwhich, nuclear receptor, family five, transcription factor, co-activator, transcription-receptor-agonist complex, transcription/receptor/agonist
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus : Q9UEC0 Q15596
• Total number of polymer chains: 4
• Total formula weight: 64028.31

Authors

Williams, S.P.,Xu, R.,Zuercher, W.J. (deposition date: 2010-11-15, release date: 2011-03-30, Last modification date: 2024-02-21)

• Primary citation: Whitby, R.J.,Stec, J.,Blind, R.D.,Dixon, S.,Leesnitzer, L.M.,Orband-Miller, L.A.,Williams, S.P.,Willson, T.M.,Xu, R.,Zuercher, W.J.,Cai, F.,Ingraham, H.A.; Small Molecule Agonists of the Orphan Nuclear Receptors Steroidogenic Factor-1 (SF-1, NR5A1) and Liver Receptor Homologue-1 (LRH-1, NR5A2).; J.Med.Chem., 54:2266-2281, 2011; PubMed: 21391689; DOI: 10.1021/jm1014296

Experimental method

X-RAY DIFFRACTION (1.75 Å)