3PJC

Crystal structure of JAK3 complexed with a potent ATP site inhibitor showing high selectivity within the Janus kinase family

Summary for 3PJC

Entry DOI	10.2210/pdb3pjc/pdb
Descriptor	Tyrosine-protein kinase JAK3, 3-(1H-indol-3-yl)-4-[2-(4-oxopiperidin-1-yl)-5-(trifluoromethyl)pyrimidin-4-yl]-1H-pyrrole-2,5-dione (3 entities in total)
Functional Keywords	small molecule inhibitor, atp site kinase inhibitor, atp-binding, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Endomembrane system; Peripheral membrane protein (By similarity): P52333
Total number of polymer chains	1
Total formula weight	36152.14
Authors	Tavares, G.A.,Thoma, G.,Zerwes, H.-G.,Kroemer, M. (deposition date: 2010-11-09, release date: 2010-12-29, Last modification date: 2024-02-21)
Primary citation	Thoma, G.,Nuninger, F.,Falchetto, R.,Hermes, E.,Tavares, G.A.,Vangrevelinghe, E.,Zerwes, H.G. Identification of a Potent Janus Kinase 3 Inhibitor with High Selectivity within the Janus Kinase Family. J.Med.Chem., 54:284-288, 2011 Cited by PubMed: 21155605 DOI: 10.1021/jm101157q PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation