3PA5
X-ray crystal structure of compound 1 bound to human CHK1 kinase domain
Summary for 3PA5
Entry DOI | 10.2210/pdb3pa5/pdb |
Descriptor | Serine/threonine-protein kinase Chk1, 2-(carbamoylamino)-5-(4-chlorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-3-carboxamide, GLYCEROL, ... (4 entities in total) |
Functional Keywords | kinase, phosphatase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O14757 |
Total number of polymer chains | 1 |
Total formula weight | 32110.39 |
Authors | Fischmann, T.O. (deposition date: 2010-10-18, release date: 2010-12-08, Last modification date: 2024-02-21) |
Primary citation | Zhao, L.,Zhang, Y.,Dai, C.,Guzi, T.,Wiswell, D.,Seghezzi, W.,Parry, D.,Fischmann, T.,Siddiqui, M.A. Design, synthesis and SAR of thienopyridines as potent CHK1 inhibitors. Bioorg.Med.Chem.Lett., 20:7216-7221, 2010 Cited by PubMed: 21074424DOI: 10.1016/j.bmcl.2010.10.105 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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