3P99

Sterol 14alpha-demethylase (CYP51) from Trypanosoma brucei in complex with delta7-14alpha-methylene-cyclopropyl-dihydrolanosterol

Summary for 3P99

Entry DOI	10.2210/pdb3p99/pdb
Related	3g1q 3gw9
Descriptor	Sterol 14-alpha-demethylase, PROTOPORPHYRIN IX CONTAINING FE, (3alpha,9beta,10alpha,13alpha)-30-cyclopropylidenelanost-7-en-3-ol, ... (4 entities in total)
Functional Keywords	cytochrome p450 fold/sterol 14-alpha demethylase, cyp51, oxidoreductase, monooxygenase, hemoprotein, sterol biosynthesis, cytochrome p450 reductase (cpr), endoplasmic reticulum, membrane
Biological source	Trypanosoma brucei
Total number of polymer chains	4
Total formula weight	209026.65
Authors	Lepesheva, G.I.,Hargrove, T.Y.,Waterman, M.R.,Wawrzak, Z. (deposition date: 2010-10-16, release date: 2011-11-30, Last modification date: 2023-09-06)
Primary citation	Hargrove, T.Y.,Wawrzak, Z.,Liu, J.,Waterman, M.R.,Nes, W.D.,Lepesheva, G.I. Structural complex of sterol 14alpha-demethylase (CYP51) with 14alpha-methylenecyclopropyl-delta7-24, 25-dihydrolanosterol J.Lipid Res., 53:311-320, 2012 Cited by PubMed: 22135275 DOI: 10.1194/jlr.M021865 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation