3P89

FXR bound to a quinolinecarboxylic acid

Summary for 3P89

• Entry DOI: 10.2210/pdb3p89/pdb
• Related: 3P88
• Descriptor: Farnesoid X receptor, Nuclear receptor coactivator 1, 6-(4-{[3-(2,6-dichlorophenyl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}phenyl)quinoline-2-carboxylic acid, ... (5 entities in total)
• Functional Keywords: nuclear receptor fxr, transcription-inhibitor complex, transcription/inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus : B6ZGS9 A8K1V4
• Total number of polymer chains: 2
• Total formula weight: 28900.84

Authors

Madauss, K.P.,Williams, S.P.,Deaton, D.N. (deposition date: 2010-10-13, release date: 2011-08-31, Last modification date: 2024-02-21)

• Primary citation: Bass, J.Y.,Caravella, J.A.,Chen, L.,Creech, K.L.,Deaton, D.N.,Madauss, K.P.,Marr, H.B.,McFadyen, R.B.,Miller, A.B.,Mills, W.Y.,Navas, F.,Parks, D.J.,Smalley, T.L.,Spearing, P.K.,Todd, D.,Williams, S.P.,Wisely, G.B.; Conformationally constrained farnesoid X receptor (FXR) agonists: Heteroaryl replacements of the naphthalene.; Bioorg.Med.Chem.Lett., 21:1206-1213, 2011; PubMed: 21256005; DOI: 10.1016/j.bmcl.2010.12.089

Experimental method

X-RAY DIFFRACTION (2.3 Å)