3P7Z
Crystal structure of the Neurofibromin Sec14-PH module containing the patient derived mutation I1584V
Summary for 3P7Z
Entry DOI | 10.2210/pdb3p7z/pdb |
Related | 2e2x |
Descriptor | Neurofibromin, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, SODIUM ION, ... (5 entities in total) |
Functional Keywords | sec14 homolgy domain, pleckstrin homology domain, binding of glycerophospholipids, glycerophospholipids, cytoplasmatic, lipid binding protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 65095.25 |
Authors | Welti, S.,Scheffzek, K. (deposition date: 2010-10-13, release date: 2010-12-08, Last modification date: 2019-07-17) |
Primary citation | Welti, S.,Kuhn, S.,D'Angelo, I.,Brugger, B.,Kaufmann, D.,Scheffzek, K. Structural and biochemical consequences of NF1 associated nontruncating mutations in the Sec14-PH module of neurofibromin. Hum.Mutat., 32:191-197, 2011 Cited by PubMed: 21089070DOI: 10.1002/humu.21405 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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