3P5R
Crystal Structure of Taxadiene Synthase from Pacific Yew (Taxus brevifolia) in complex with Mg2+ and 2-fluorogeranylgeranyl diphosphate
Summary for 3P5R
Entry DOI | 10.2210/pdb3p5r/pdb |
Related | 3P5P |
Descriptor | Taxadiene synthase, MAGNESIUM ION, (2Z,6E,10E)-2-fluoro-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl trihydrogen diphosphate, ... (4 entities in total) |
Functional Keywords | class i and ii terpene cyclase fold, diterpene cyclase, ddxxd motif, nse/dte motif, 2-fluoro-geranylgeranyl diphosphate, biosynthesis of paclitaxel, lyase |
Biological source | Taxus brevifolia (Pacific yew) |
Total number of polymer chains | 2 |
Total formula weight | 176685.95 |
Authors | Koksal, M.,Christianson, D.W. (deposition date: 2010-10-10, release date: 2010-12-29, Last modification date: 2023-09-06) |
Primary citation | Koksal, M.,Jin, Y.,Coates, R.M.,Croteau, R.,Christianson, D.W. Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis. Nature, 469:116-120, 2011 Cited by PubMed: 21160477DOI: 10.1038/nature09628 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.247 Å) |
Structure validation
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