3P3P
Factor inhibiting HIF-1 Alpha in complex with Notch 1 fragment mouse notch (1997-2016) peptide
Summary for 3P3P
Entry DOI | 10.2210/pdb3p3p/pdb |
Related | 1H2K 1H2L 1H2M 2QC9 2ZGD 3D8C 3P3N |
Descriptor | Hypoxia-inducible factor 1-alpha inhibitor, Notch 1 protein, FE (II) ION, ... (7 entities in total) |
Functional Keywords | double stranded beta-helix, hydroxylase, iron binding, 2-oxoglutarate binding, hypoxia inducible factor binding, ankyrin repeat domain binding, oxidoreductase-transcription complex, oxidoreductase/transcription |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus (Potential): Q9NWT6 |
Total number of polymer chains | 2 |
Total formula weight | 42927.68 |
Authors | McDonough, M.A.,Schofield, C.J. (deposition date: 2010-10-05, release date: 2010-11-24, Last modification date: 2024-02-21) |
Primary citation | Coleman, M.L.,Mcdonough, M.A.,Hewitson, K.S.,Coles, C.,Mecinovic, J.,Edelmann, M.,Cook, K.M.,Cockman, M.E.,Lancaster, D.E.,Kessler, B.M.,Oldham, N.J.,Ratcliffe, P.J.,Schofield, C.J. Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor J.Biol.Chem., 282:24027-24038, 2007 Cited by PubMed: 17573339PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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