3OYS
Human Carbonic Anhydrase II complexed with 2-{[4-AMINO-3-(3-HYDROXYPROP-1-YN-1-YL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1-YL]METHYL}-5-METHYL-3-(2-METHYLPHENYL)QUINAZOLIN-4(3H)-ONE
Summary for 3OYS
Entry DOI | 10.2210/pdb3oys/pdb |
Related | 3OY0 3OYQ |
Descriptor | Carbonic anhydrase 2, GLYCEROL, ZINC ION, ... (6 entities in total) |
Functional Keywords | benzene sulphonamide inhibitor, drug interactions, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29815.04 |
Authors | Aggarwal, M.,McKenna, R. (deposition date: 2010-09-23, release date: 2011-08-10, Last modification date: 2024-02-21) |
Primary citation | Hen, N.,Bialer, M.,Yagen, B.,Maresca, A.,Aggarwal, M.,Robbins, A.H.,McKenna, R.,Scozzafava, A.,Supuran, C.T. Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV. J.Med.Chem., 54:3977-3981, 2011 Cited by PubMed: 21506569DOI: 10.1021/jm200209n PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.538 Å) |
Structure validation
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