3OY3
Crystal structure of ABL T315I mutant kinase domain bound with a DFG-out inhibitor AP24589
Summary for 3OY3
Entry DOI | 10.2210/pdb3oy3/pdb |
Related | 3IK3 3OXZ |
Descriptor | Tyrosine-protein kinase ABL1, 5-[(5-{[4-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-3-(trifluoromethyl)phenyl]carbamoyl}-2-methylphenyl)ethynyl]-1-methyl-1H-imidazole-2-carboxamide (3 entities in total) |
Functional Keywords | protein-inhibitor complex, protein kinase two-domain fold, phosphotransferase, atp binding, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Mus musculus (mouse) |
Cellular location | Cytoplasm, cytoskeleton: P00520 |
Total number of polymer chains | 2 |
Total formula weight | 66756.16 |
Authors | Zhou, T.,Commodore, L.,Huang, W.S.,Wang, Y.,Thomas, M.,Keats, J.,Xu, Q.,Rivera, V.,Shakespeare, W.C.,Clackson, T.,Dalgarno, D.C.,Zhu, X. (deposition date: 2010-09-22, release date: 2010-12-15, Last modification date: 2023-09-06) |
Primary citation | Zhou, T.,Commodore, L.,Huang, W.S.,Wang, Y.,Thomas, M.,Keats, J.,Xu, Q.,Rivera, V.M.,Shakespeare, W.C.,Clackson, T.,Dalgarno, D.C.,Zhu, X. Structural Mechanism of the Pan-BCR-ABL Inhibitor Ponatinib (AP24534): Lessons for Overcoming Kinase Inhibitor Resistance. Chem.Biol.Drug Des., 77:1-11, 2011 Cited by PubMed: 21118377DOI: 10.1111/j.1747-0285.2010.01054.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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