3ORN

Mitogen-activated protein kinase kinase 1 (MEK1) in complex with CH4987655 and MgAMP-PNP

Summary for 3ORN

• Entry DOI: 10.2210/pdb3orn/pdb
• Related: 3OS3
• Descriptor: Dual specificity mitogen-activated protein kinase kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (7 entities in total)
• Functional Keywords: kinase, kinase inhibitor, allosteric, mitogen-activated protein kinase kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : Q02750
• Total number of polymer chains: 1
• Total formula weight: 36061.77

Authors

Lukacs, C.M.,Janson, C.,Schuck, V.,Belunis, C. (deposition date: 2010-09-07, release date: 2011-03-02, Last modification date: 2024-02-21)

• Primary citation: Isshiki, Y.,Kohchi, Y.,Iikura, H.,Matsubara, Y.,Asoh, K.,Murata, T.,Kohchi, M.,Mizuguchi, E.,Tsujii, S.,Hattori, K.,Miura, T.,Yoshimura, Y.,Aida, S.,Miwa, M.,Saitoh, R.,Murao, N.,Okabe, H.,Belunis, C.,Janson, C.,Lukacs, C.,Schuck, V.,Shimma, N.; Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent.; Bioorg.Med.Chem.Lett., 21:1795-1801, 2011; PubMed: 21316218; DOI: 10.1016/j.bmcl.2011.01.062

Experimental method

X-RAY DIFFRACTION (2.8 Å)