3OOI

Crystal Structure of Human Histone-Lysine N-methyltransferase NSD1 SET domain in Complex with S-adenosyl-L-methionine

Summary for 3OOI

• Entry DOI: 10.2210/pdb3ooi/pdb
• Descriptor: Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, ZINC ION, SULFATE ION, ... (5 entities in total)
• Functional Keywords: set domain, histone-lysine n-methyltransferase, s-adenosyl-l-methionine, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q96L73
• Total number of polymer chains: 1
• Total formula weight: 27313.03

Authors

Qiao, Q.,Wang, M.,Xu, R.M. (deposition date: 2010-08-31, release date: 2010-12-22, Last modification date: 2024-03-20)

• Primary citation: Qiao, Q.,Li, Y.,Chen, Z.,Wang, M.,Reinberg, D.,Xu, R.M.; The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation; J.Biol.Chem., 286:8361-8368, 2010; PubMed: 21196496; DOI: 10.1074/jbc.M110.204115

Experimental method

X-RAY DIFFRACTION (1.75 Å)