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3OOI

Crystal Structure of Human Histone-Lysine N-methyltransferase NSD1 SET domain in Complex with S-adenosyl-L-methionine

Summary for 3OOI
Entry DOI10.2210/pdb3ooi/pdb
DescriptorHistone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, ZINC ION, SULFATE ION, ... (5 entities in total)
Functional Keywordsset domain, histone-lysine n-methyltransferase, s-adenosyl-l-methionine, transferase
Biological sourceHomo sapiens (human)
Cellular locationNucleus: Q96L73
Total number of polymer chains1
Total formula weight27313.03
Authors
Qiao, Q.,Wang, M.,Xu, R.M. (deposition date: 2010-08-31, release date: 2010-12-22, Last modification date: 2024-03-20)
Primary citationQiao, Q.,Li, Y.,Chen, Z.,Wang, M.,Reinberg, D.,Xu, R.M.
The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation
J.Biol.Chem., 286:8361-8368, 2010
Cited by
PubMed: 21196496
DOI: 10.1074/jbc.M110.204115
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.75 Å)
Structure validation

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