3OHI

Structure of Giardia fructose-1,6-biphosphate aldolase in complex with 3-hydroxy-2-pyridone

Summary for 3OHI

• Entry DOI: 10.2210/pdb3ohi/pdb
• Related: 2ISV 2ISW 3GAK 3GAY 3GB6
• Descriptor: Putative fructose-1,6-bisphosphate aldolase, ZINC ION, ({3-hydroxy-2-oxo-4-[2-(phosphonooxy)ethyl]pyridin-1(2H)-yl}methyl)phosphonic acid, ... (4 entities in total)
• Functional Keywords: class ii fructose-1, 6-bisphosphate aldolase, glycolytic pathway, lyase
• Biological source: Giardia intestinalis (Giardia intestinalis)
• Total number of polymer chains: 2
• Total formula weight: 71376.66

Authors

Herzberg, O.,Galkin, A. (deposition date: 2010-08-17, release date: 2011-01-19, Last modification date: 2023-09-06)

• Primary citation: Li, Z.,Liu, Z.,Cho, D.W.,Zou, J.,Gong, M.,Breece, R.M.,Galkin, A.,Li, L.,Zhao, H.,Maestas, G.D.,Tierney, D.L.,Herzberg, O.,Dunaway-Mariano, D.,Mariano, P.S.; Rational design, synthesis and evaluation of first generation inhibitors of the Giardia lamblia fructose-1,6-biphosphate aldolase.; J.Inorg.Biochem., 105:509-517, 2010; PubMed: 21333622; DOI: 10.1016/j.jinorgbio.2010.12.012

Experimental method

X-RAY DIFFRACTION (2.3 Å)