3ODI
Crystal structure of cyclophilin A in complex with Voclosporin E-ISA247
Summary for 3ODI
| Entry DOI | 10.2210/pdb3odi/pdb |
| Related | 3ODL |
| Descriptor | Cyclophilin A, Voclosporin (3 entities in total) |
| Functional Keywords | calcineurin inhibition, calcineurin, cyclosporin, psoriasis, immunosuppressant, voclosporin, isomerase-immunosuppressant complex, isomerase/immunosuppressant |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 20 |
| Total formula weight | 192691.39 |
| Authors | Kuglstatter, A.,Stihle, M.,Benz, J.,Hennig, M. (deposition date: 2010-08-11, release date: 2011-02-16, Last modification date: 2023-12-06) |
| Primary citation | Kuglstatter, A.,Mueller, F.,Kusznir, E.,Gsell, B.,Stihle, M.,Thoma, R.,Benz, J.,Aspeslet, L.,Freitag, D.,Hennig, M. Structural basis for the cyclophilin A binding affinity and immunosuppressive potency of E-ISA247 (voclosporin). Acta Crystallogr.,Sect.D, 67:119-123, 2011 Cited by PubMed: 21245533DOI: 10.1107/S0907444910051905 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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