3OB1
Crystal structure of c-Cbl TKB domain in complex with double phosphorylated Spry2 peptide
Summary for 3OB1
Entry DOI | 10.2210/pdb3ob1/pdb |
Related | 3OB2 |
Descriptor | 12-meric peptide from Protein sprouty homolog 2, E3 ubiquitin-protein ligase CBL (3 entities in total) |
Functional Keywords | protein-peptide complex, double phosphorylation, complex, e3 ubiquitin ligase, spry2, phosphorylation, ligase-signaling protein complex, ligase/signaling protein |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm, cytoskeleton : O43597 Cytoplasm: P22681 |
Total number of polymer chains | 2 |
Total formula weight | 39747.50 |
Authors | Sun, Q.,Sivaraman, J. (deposition date: 2010-08-06, release date: 2010-08-18, Last modification date: 2023-12-06) |
Primary citation | Sun, Q.,Jackson, R.A.,Ng, C.,Guy, G.R.,Sivaraman, J. Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain Plos One, 5:e12819-e12819, 2010 Cited by PubMed: 20877636DOI: 10.1371/journal.pone.0012819 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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