3O73

Crystal structure of quinone reductase 2 in complex with the indolequinone MAC627

Summary for 3O73

• Entry DOI: 10.2210/pdb3o73/pdb
• Related: 1QR2
• Descriptor: Ribosyldihydronicotinamide dehydrogenase [quinone], ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total)
• Functional Keywords: quinone reductase 2, nqo2, oxidoreductase, flavoprotein, indolequinone mac627, fad, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P16083
• Total number of polymer chains: 2
• Total formula weight: 56145.62

Authors

Dufour, M.,Yan, C.,Colucci, M.A.,Siegel, D.,Li, Y.,De Matteis, C.I.,Ross, D.,Moody, C.J. (deposition date: 2010-07-30, release date: 2011-05-11, Last modification date: 2023-09-06)

• Primary citation: Dufour, M.,Yan, C.,Siegel, D.,Colucci, M.A.,Jenner, M.,Oldham, N.J.,Gomez, J.,Reigan, P.,Li, Y.,De Matteis, C.I.,Ross, D.,Moody, C.J.; Mechanism-Based Inhibition of Quinone Reductase 2 (NQO2): Selectivity for NQO2 over NQO1 and Structural Basis for Flavoprotein Inhibition.; Chembiochem, 12:1203-1208, 2011; PubMed: 21506232; DOI: 10.1002/cbic.201100085

Experimental method

X-RAY DIFFRACTION (2 Å)