3NZU
Structure-based Optimization of Pyrazolo -Pyrimidine and -Pyridine Inhibitors of PI3-Kinase
Summary for 3NZU
Entry DOI | 10.2210/pdb3nzu/pdb |
Related | 3NZS |
Descriptor | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 6-(2H-indazol-4-yl)-1-methyl-N-[3-(methylsulfonyl)propyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine (2 entities in total) |
Functional Keywords | kinase p110, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 109767.06 |
Authors | Murray, J.M.,Wiesmann, C. (deposition date: 2010-07-16, release date: 2010-12-29, Last modification date: 2024-02-21) |
Primary citation | Staben, S.T.,Heffron, T.P.,Sutherlin, D.P.,Bhat, S.R.,Castanedo, G.M.,Chuckowree, I.S.,Dotson, J.,Folkes, A.J.,Friedman, L.S.,Lee, L.,Lesnick, J.,Lewis, C.,Murray, J.M.,Nonomiya, J.,Olivero, A.G.,Plise, E.,Pang, J.,Prior, W.W.,Salphati, L.,Rouge, L.,Sampath, D.,Tsui, V.,Wan, N.C.,Wang, S.,Wiesmann, C.,Wu, P.,Zhu, B.Y. Structure-based optimization of pyrazolo-pyrimidine and -pyridine inhibitors of PI3-kinase. Bioorg.Med.Chem.Lett., 20:6048-6051, 2010 Cited by PubMed: 20822905DOI: 10.1016/j.bmcl.2010.08.067 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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