3NPC
Crystal structure of JNK2 complexed with BIRB796
Summary for 3NPC
Entry DOI | 10.2210/pdb3npc/pdb |
Descriptor | Mitogen-activated protein kinase 9, 1-(5-TERT-BUTYL-2-P-TOLYL-2H-PYRAZOL-3-YL)-3-[4-(2-MORPHOLIN-4-YL-ETHOXY)-NAPHTHALEN-1-YL]-UREA (3 entities in total) |
Functional Keywords | dfg-out, protein kinase, transferase, atp binding, type ii kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 84847.97 |
Authors | Kuglstatter, A.,Ghate, M. (deposition date: 2010-06-28, release date: 2010-08-11, Last modification date: 2023-09-06) |
Primary citation | Kuglstatter, A.,Ghate, M.,Tsing, S.,Villasenor, A.G.,Shaw, D.,Barnett, J.W.,Browner, M.F. X-ray crystal structure of JNK2 complexed with the p38alpha inhibitor BIRB796: Insights into the rational design of DFG-out binding MAP kinase inhibitors. Bioorg.Med.Chem.Lett., 20:5217-5220, 2010 Cited by PubMed: 20655210DOI: 10.1016/j.bmcl.2010.06.157 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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