3NMQ

Hsp90b N-terminal domain in complex with EC44, a pyrrolo-pyrimidine methoxypyridine inhibitor

Summary for 3NMQ

Entry DOI	10.2210/pdb3nmq/pdb
Descriptor	Heat shock protein HSP 90-beta, 5-{2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-methylpent-4-yn-2 -ol (3 entities in total)
Functional Keywords	atpase, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P08238
Total number of polymer chains	1
Total formula weight	27100.02
Authors	Arndt, J.W.,Yun, T.J.,Harning, E.K.,Giza, K.,Rabah, D.,Li, P.,Luchetti, D.,Shi, J.,Manning, A.,Kehry, M.R. (deposition date: 2010-06-22, release date: 2010-12-22, Last modification date: 2024-03-13)
Primary citation	Yun, T.J.,Harning, E.K.,Giza, K.,Rabah, D.,Li, P.,Arndt, J.W.,Luchetti, D.,Biamonte, M.A.,Shi, J.,Lundgren, K.,Manning, A.,Kehry, M.R. EC144, a Synthetic Inhibitor of Heat Shock Protein 90, Blocks Innate and Adaptive Immune Responses in Models of Inflammation and Autoimmunity. J.Immunol., 186:563-575, 2011 Cited by PubMed: 21131419 DOI: 10.4049/jimmunol.1000222 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation