3NI5

Carbonic anhydrase inhibitor: C1 family

Summary for 3NI5

• Entry DOI: 10.2210/pdb3ni5/pdb
• Related: 3NJ9
• Descriptor: Carbonic anhydrase 2, ZINC ION, MERCURY (II) ION, ... (5 entities in total)
• Functional Keywords: carbonic anhydrase, inhibitors, sulfonamide, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : P00918
• Total number of polymer chains: 1
• Total formula weight: 30036.54

Authors

Temperini, C.,Cecchi, A.,Scozzafava, A.,Supuran, C.T. (deposition date: 2010-06-15, release date: 2011-06-22, Last modification date: 2023-11-01)

• Primary citation: Mincione, F.,Benedini, F.,Biondi, S.,Cecchi, A.,Temperini, C.,Formicola, G.,Pacileo, I.,Scozzafava, A.,Masini, E.,Supuran, C.T.; Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action; Bioorg.Med.Chem.Lett., 21:3216-3221, 2011; PubMed: 21549597; DOI: 10.1016/j.bmcl.2011.04.046

Experimental method

X-RAY DIFFRACTION (2.1 Å)