3NHN
Crystal structure of the SRC-family kinase HCK SH3-SH2-linker regulatory region
Summary for 3NHN
Entry DOI | 10.2210/pdb3nhn/pdb |
Descriptor | Tyrosine-protein kinase HCK (2 entities in total) |
Functional Keywords | hck, sh3-sh2-linker, src family kinase, sfk, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 1: Lysosome. Isoform 2: Cell membrane ; Lipid-anchor . Cytoplasmic vesicle, secretory vesicle: P08631 |
Total number of polymer chains | 1 |
Total formula weight | 22311.91 |
Authors | Alvarado, J.J.,Betts, L.,Moroco, J.A.,Smithgall, T.E.,Yeh, J.I. (deposition date: 2010-06-14, release date: 2010-09-01, Last modification date: 2023-09-06) |
Primary citation | Alvarado, J.J.,Betts, L.,Moroco, J.A.,Smithgall, T.E.,Yeh, J.I. Crystal Structure of the Src Family Kinase Hck SH3-SH2 Linker Regulatory Region Supports an SH3-dominant Activation Mechanism. J.Biol.Chem., 285:35455-35461, 2010 Cited by PubMed: 20810664DOI: 10.1074/jbc.M110.145102 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.61 Å) |
Structure validation
Download full validation report