3NEW
p38-alpha complexed with Compound 10
Summary for 3NEW
Entry DOI | 10.2210/pdb3new/pdb |
Descriptor | Mitogen-activated protein kinase 14, 4-(trifluoromethyl)-3-[3-(trifluoromethyl)phenyl]-1,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-one (2 entities in total) |
Functional Keywords | kinase, ser/thr kinase, intracellular, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 42330.09 |
Authors | Goedken, E.R.,Comess, K.M.,Sun, C.,Argiriadi, M.,Jia, Y.,Quinn, C.M.,Banach, D.L.,Marcotte, D.,Borhani, D. (deposition date: 2010-06-09, release date: 2010-12-01, Last modification date: 2024-02-21) |
Primary citation | Comess, K.M.,Sun, C.,Abad-Zapatero, C.,Goedken, E.R.,Gum, R.J.,Borhani, D.W.,Argiriadi, M.,Groebe, D.R.,Jia, Y.,Clampit, J.E.,Haasch, D.L.,Smith, H.T.,Wang, S.,Song, D.,Coen, M.L.,Cloutier, T.E.,Tang, H.,Cheng, X.,Quinn, C.,Liu, B.,Xin, Z.,Liu, G.,Fry, E.H.,Stoll, V.,Ng, T.I.,Banach, D.,Marcotte, D.,Burns, D.J.,Calderwood, D.J.,Hajduk, P.J. Discovery and Characterization of Non-ATP Site Inhibitors of the Mitogen Activated Protein (MAP) Kinases. Acs Chem.Biol., 6:234-244, 2011 Cited by PubMed: 21090814DOI: 10.1021/cb1002619 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.51 Å) |
Structure validation
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