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3N68

Structure of endothelial nitric oxide synthase heme domain N368D/V106M double mutant complexed with 4-(3-(2-(6-amino-4-methylpyridin-2-yl)ethyl)phenethyl)-6-methylpyridin-2-amine

Summary for 3N68

Related3N5P 3N5Q 3N5R 3N5S 3N5T 3N5V 3N5W 3N5X 3N5Y 3N5Z 3N60 3N61 3N62 3N63 3N64 3N65 3N66 3N67 3N69 3N6A 3N6B 3N6C 3N6D 3N6E 3N6F 3N6G 
Descriptor'Nitric oxide synthase (E.C.1.14.13.39)
Functional Keywordsnitric oxide synthase, heme enzyme, substrate inhibitor, OXIDOREDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex,OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR
Biological sourceBos taurus (cow)
Cellular locationCell membrane, sarcolemma; Peripheral membrane protein (By similarity) P29476 
Total number of polymer chains2
Total molecular weight102539.6
Authors
Delker, S.L.,Li, H.,Poulos, T.L. (deposition date: 2010-05-25, release date: 2011-02-09)
Primary citation
Delker, S.L.,Xue, F.,Li, H.,Jamal, J.,Silverman, R.B.,Poulos, T.L.
Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49:10803-10810, 2010
PubMed: 21138269
DOI: 10.1021/bi1013479
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.53 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25650.1%6.1%3.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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rotated about x axis by 90°
rotated about y axis by 90°
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106858
entries available on 2015-02-25
00:00 UTC / 09:00 JST