3MXY
Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications.
Summary for 3MXY
Entry DOI | 10.2210/pdb3mxy/pdb |
Related | 1JYQ 1JYR 3KFJ 3MXC |
Descriptor | Growth factor receptor-bound protein 2, AICD peptide E683V variant (3 entities in total) |
Functional Keywords | protein-peptide complex, aicd, grb2-sh2, protein binding, alzheimer's disease, app |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P62993 |
Total number of polymer chains | 2 |
Total formula weight | 12864.38 |
Authors | |
Primary citation | Das, S.,Raychaudhuri, M.,Sen, U.,Mukhopadhyay, D. Functional Implications of the Conformational Switch in AICD Peptide upon Binding to Grb2-SH2 Domain. J.Mol.Biol., 414:217-230, 2011 Cited by PubMed: 22001015DOI: 10.1016/j.jmb.2011.09.046 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report