3MO7

Crystal structure of human orotidine 5'-monophosphate decarboxylase covalently modified by 2'-fluoro-6-iodo-UMP

Summary for 3MO7

Entry DOI	10.2210/pdb3mo7/pdb
Related	2EAW 2P1F 3BGG 3BGJ 3BKO 3G3D
Descriptor	Uridine 5'-monophosphate synthase, 2'-deoxy-2'-fluorouridine 5'-(dihydrogen phosphate), GLYCEROL, ... (4 entities in total)
Functional Keywords	ump synthase, orotidine 5'-monophosphate decarboxylase, 2'-fluoro-6-iodo-ump, lyase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	30890.43
Authors	Liu, Y.,Kotra, L.P.,Pai, E.F. (deposition date: 2010-04-22, release date: 2011-04-06, Last modification date: 2023-09-06)
Primary citation	Lewis, M.,Meza-Avina, M.E.,Wei, L.,Crandall, I.E.,Bello, A.M.,Poduch, E.,Liu, Y.,Paige, C.J.,Kain, K.C.,Pai, E.F.,Kotra, L.P. Novel interactions of fluorinated nucleotide derivatives targeting orotidine 5'-monophosphate decarboxylase. J.Med.Chem., 54:2891-2901, 2011 Cited by PubMed: 21417464 DOI: 10.1021/jm101642g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation