3MMF
Crystal structure of human carbonic anhydrase II in complex with a 1,3,5-triazine-substituted benzenesulfonamide inhibitor
Summary for 3MMF
Entry DOI | 10.2210/pdb3mmf/pdb |
Related | 3ML2 |
Descriptor | Carbonic anhydrase 2, ZINC ION, 4-({4-chloro-6-[(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl}amino)benzenesulfonamide, ... (5 entities in total) |
Functional Keywords | zinc metalloenzyme, inhibitor, sulfonamide, metal-binding, triazine, lyase, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29791.34 |
Authors | Avvaru, B.S.,Wagner, J.,Robbins, A.H.,Mckenna, R. (deposition date: 2010-04-19, release date: 2011-04-20, Last modification date: 2023-09-06) |
Primary citation | Carta, F.,Garaj, V.,Maresca, A.,Wagner, J.,Avvaru, B.S.,Robbins, A.H.,Scozzafava, A.,McKenna, R.,Supuran, C.T. Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies. Bioorg.Med.Chem., 19:3105-3119, 2011 Cited by PubMed: 21515057DOI: 10.1016/j.bmc.2011.04.005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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