3MJR
Human dCK complex with Acyclic Nucleoside
Summary for 3MJR
Entry DOI | 10.2210/pdb3mjr/pdb |
Descriptor | Deoxycytidine kinase, 9-HYROXYETHOXYMETHYLGUANINE, URIDINE-5'-DIPHOSPHATE, ... (4 entities in total) |
Functional Keywords | acv, gcv, dck, kinase, udp, p-loop, kinase activity, nucleoside kinase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : P27707 |
Total number of polymer chains | 4 |
Total formula weight | 132582.30 |
Authors | |
Primary citation | Hazra, S.,Konrad, M.,Lavie, A. The Sugar Ring of the Nucleoside Is Required for Productive Substrate Positioning in the Active Site of Human Deoxycytidine Kinase (dCK): Implications for the Development of dCK-Activated Acyclic Guanine Analogues. J.Med.Chem., 53:5792-5800, 2010 Cited by PubMed: 20684612DOI: 10.1021/jm1005379 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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