3MA3
Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a naphtho-difuran ligand
Summary for 3MA3
Entry DOI | 10.2210/pdb3ma3/pdb |
Descriptor | Proto-oncogene serine/threonine-protein kinase pim-1, Pimtide, naphtho[2,1-b:7,6-b']difuran-2,8-dicarboxylic acid, ... (4 entities in total) |
Functional Keywords | oncogene, kinase, serine-threonine, pim1, structural genomics consortium, sgc, alternative initiation, atp-binding, manganese, membrane, metal-binding, nucleotide-binding, nucleus, phosphoprotein, proto-oncogene, serine/threonine-protein kinase, transferase, host-virus interaction, viral immunoevasion, virion, virulence, cell cycle, cell membrane |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309 |
Total number of polymer chains | 2 |
Total formula weight | 36907.82 |
Authors | Filippakopoulos, P.,Bullock, A.,Fedorov, O.,Vollmar, M.,von Delft, F.,Cochet, C.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2010-03-23, release date: 2010-04-14, Last modification date: 2023-09-06) |
Primary citation | Lopez-Ramos, M.,Prudent, R.,Moucadel, V.,Sautel, C.F.,Barette, C.,Lafanechere, L.,Mouawad, L.,Grierson, D.,Schmidt, F.,Florent, J.C.,Filippakopoulos, P.,Bullock, A.N.,Knapp, S.,Reiser, J.B.,Cochet, C. New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights. Faseb J., 24:3171-3185, 2010 Cited by PubMed: 20400536DOI: 10.1096/fj.09-143743 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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