3M6H
Crystal Structure of Post-isomerized Ertapenem Covalent Adduct with TB B-lactamase
Summary for 3M6H
| Entry DOI | 10.2210/pdb3m6h/pdb |
| Related | 3M6B |
| Descriptor | Beta-lactamase, PHOSPHATE ION, (2S,3R,4S)-4-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-2-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, ... (4 entities in total) |
| Functional Keywords | alpha-beta structure, antibiotic resistance, cell membrane, hydrolase, lipoprotein, membrane, palmitate, hydrolase-antibiotic complex, hydrolase/antibiotic |
| Biological source | Mycobacterium tuberculosis |
| Total number of polymer chains | 1 |
| Total formula weight | 28940.19 |
| Authors | Tremblay, L.W. (deposition date: 2010-03-15, release date: 2010-04-14, Last modification date: 2023-09-06) |
| Primary citation | Tremblay, L.W.,Fan, F.,Blanchard, J.S. Biochemical and structural characterization of Mycobacterium tuberculosis beta-lactamase with the carbapenems ertapenem and doripenem. Biochemistry, 49:3766-3773, 2010 Cited by PubMed: 20353175DOI: 10.1021/bi100232q PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.994 Å) |
Structure validation
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