3M1J
The crystal structure of a NAMI A-Carbonic Anhydrase II adduct discloses the mode of action of this novel anticancer metallodrug
Summary for 3M1J
| Entry DOI | 10.2210/pdb3m1j/pdb |
| Descriptor | Carbonic anhydrase 2, ZINC ION, RUTHENIUM ION, ... (7 entities in total) |
| Functional Keywords | ruthenium complexes, nami-a, antimetastatic agents, carbonic anhydrase, lyase |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm : P00918 |
| Total number of polymer chains | 1 |
| Total formula weight | 29924.46 |
| Authors | Temperini, C.,Messori, L. (deposition date: 2010-03-05, release date: 2011-01-19, Last modification date: 2023-11-01) |
| Primary citation | Casini, A.,Temperini, C.,Gabbiani, C.,Supuran, C.T.,Messori, L. The x-ray structure of the adduct between NAMI-A and carbonic anhydrase provides insights into the reactivity of this metallodrug with proteins Chemmedchem, 5:1989-1994, 2010 Cited by PubMed: 20931644DOI: 10.1002/cmdc.201000331 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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