3M08
Wild Type Dihydrofolate Reductase from Staphylococcus aureus with inhibitor RAB1
Summary for 3M08
Entry DOI | 10.2210/pdb3m08/pdb |
Related | 3M09 |
Descriptor | Dihydrofolate reductase, 5-(3,4-dimethoxy-5-{(1E)-3-oxo-3-[(1S)-1-propylphthalazin-2(1H)-yl]prop-1-en-1-yl}benzyl)pyrimidine-2,4-diamine, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
Functional Keywords | folate, dhfr, antimicrobial, antibiotic resistance, nadp, one-carbon metabolism, oxidoreductase', oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Staphylococcus aureus |
Total number of polymer chains | 1 |
Total formula weight | 19762.14 |
Authors | Bourne, C.R.,Barrow, W.W. (deposition date: 2010-03-02, release date: 2010-07-14, Last modification date: 2024-02-21) |
Primary citation | Bourne, C.R.,Barrow, E.W.,Bunce, R.A.,Bourne, P.C.,Berlin, K.D.,Barrow, W.W. Inhibition of Antibiotic-Resistant Staphylococcus aureus by the Broad-Spectrum Dihydrofolate Reductase Inhibitor RAB1. Antimicrob.Agents Chemother., 54:3825-3833, 2010 Cited by PubMed: 20606069DOI: 10.1128/AAC.00361-10 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.014 Å) |
Structure validation
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