3LS4

Crystal Structure of Anti-tetrahydrocannabinol Fab Fragment in Complex with THC

Summary for 3LS4

Entry DOI	10.2210/pdb3ls4/pdb
Related	3LS5
Descriptor	Light chain of antibody Fab fragment, Heavy chain of antibody Fab fragment, (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol, ... (4 entities in total)
Functional Keywords	immune system, antibody, immunoglobulin, fab fragment, cannabinoid complex
Biological source	Mus musculus More
Total number of polymer chains	2
Total formula weight	47032.73
Authors	Niemi, M.H.,Rouvinen, J. (deposition date: 2010-02-12, release date: 2010-06-02, Last modification date: 2024-04-03)
Primary citation	Niemi, M.H.,Turunen, L.,Pulli, T.,Nevanen, T.K.,Hoyhtya, M.,Soderlund, H.,Rouvinen, J.,Takkinen, K. A structural insight into the molecular recognition of a (-)-Delta9-tetrahydrocannabinol and the development of a sensitive, one-step, homogeneous immunocomplex-based assay for its detection J.Mol.Biol., 400:803-814, 2010 Cited by PubMed: 20630472 DOI: 10.1016/j.jmb.2010.05.048 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation