3LQ5
Structure of CDK9/CyclinT in complex with S-CR8
Summary for 3LQ5
Entry DOI | 10.2210/pdb3lq5/pdb |
Related | 3BLH 3BLQ 3BLR |
Descriptor | Cell division protein kinase 9, Cyclin-T1, (2S)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol, ... (4 entities in total) |
Functional Keywords | transcriptional cdk-cyclin complex, phosphorylated, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transcription regulation, transferase, cell cycle, cell division, host-virus interaction, transcription-inhibitor complex, transcription/inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P50750 O60563 |
Total number of polymer chains | 2 |
Total formula weight | 68605.04 |
Authors | Hole, A.J.,Endicott, J.A.,Baumli, S. (deposition date: 2010-02-08, release date: 2011-01-19, Last modification date: 2023-11-01) |
Primary citation | Bettayeb, K.,Baunbak, D.,Delehouze, C.,Loaec, N.,Hole, A.J.,Baumli, S.,Endicott, J.A.,Douc-Rasy, S.,Benard, J.,Oumata, N.,Galons, H.,Meijer, L. CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells Genes Cancer, 1:369-380, 2010 Cited by PubMed: 21779453DOI: 10.1177/1947601910369817 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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