3LOK
Drug resistant cSrc kinase domain in complex with covalent inhibitor PD168393
Summary for 3LOK
Entry DOI | 10.2210/pdb3lok/pdb |
Related | 2HWP 2QI8 2QLQ 2QQ7 |
Descriptor | Proto-oncogene tyrosine-protein kinase Src, N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE (3 entities in total) |
Functional Keywords | src kinase domain, drug resistance, irreversible inhibitor, covalent inhibitor, pd168393, atp-binding, kinase, lipoprotein, myristate, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, tyrosine-protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Gallus gallus (chicken) |
Cellular location | Cell membrane (By similarity): P00523 |
Total number of polymer chains | 2 |
Total formula weight | 66284.03 |
Authors | Gruetter, C.,Rode, H.B.,Rauh, D. (deposition date: 2010-02-04, release date: 2010-12-22, Last modification date: 2023-11-01) |
Primary citation | Klueter, S.,Simard, J.R.,Rode, H.B.,Gruetter, C.,Pawar, V.,Raaijmakers, H.C.,Barf, T.A.,Rabiller, M.,van Otterlo, W.A.L.,Rauh, D. Characterization of irreversible kinase inhibitors by directly detecting covalent bond formation: a tool for dissecting kinase drug resistance Chembiochem, 11:2557-2566, 2010 Cited by PubMed: 21080395DOI: 10.1002/cbic.201000352 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.48 Å) |
Structure validation
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