3LM5
Crystal Structure of human Serine/Threonine Kinase 17B (STK17B) in complex with Quercetin
Summary for 3LM5
Entry DOI | 10.2210/pdb3lm5/pdb |
Related | 3EHA |
Descriptor | Serine/threonine-protein kinase 17B, 3,5,7,3',4'-PENTAHYDROXYFLAVONE (3 entities in total) |
Functional Keywords | stk17b, serine/threonine kinase 17b, drak2, dap kinase related apoptosis-inducing protein kinase 2, death-associated protein kinase-related 2, structural genomics, structural genomics consortium, sgc, apoptosis, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 37629.32 |
Authors | Ugochukwu, E.,Soundararajan, M.,Rellos, P.,Fedorov, O.,Phillips, C.,Wang, J.,Hapka, E.,Filippakopoulos, P.,Chaikuad, A.,Pike, A.C.W.,Carpenter, L.,Vollmar, M.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2010-01-29, release date: 2010-03-16, Last modification date: 2023-09-06) |
Primary citation | Picado, A.,Chaikuad, A.,Wells, C.I.,Shrestha, S.,Zuercher, W.J.,Pickett, J.E.,Kwarcinski, F.E.,Sinha, P.,de Silva, C.S.,Zutshi, R.,Liu, S.,Kannan, N.,Knapp, S.,Drewry, D.H.,Willson, T.M. A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation. J.Med.Chem., 63:14626-14646, 2020 Cited by PubMed: 33215924DOI: 10.1021/acs.jmedchem.0c01174 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.29 Å) |
Structure validation
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