3LDO

Crystal structure of human GRP78 (70kDa heat shock protein 5 / BIP) ATPase domain in complex with AMPPNP

Summary for 3LDO

• Entry DOI: 10.2210/pdb3ldo/pdb
• Related: 3LDL 3LDN 3LDP 3LDQ
• Descriptor: 78 kDa glucose-regulated protein, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER (3 entities in total)
• Functional Keywords: grp78, hsp70, hsc70, chaperone, heat shock, protein folding, atp-binding, adenosine, nucleoside, nucleotide-binding, stress response, small molecule inhibitor, selectivity, endoplasmic reticulum, phosphoprotein
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum lumen: P11021
• Total number of polymer chains: 2
• Total formula weight: 85612.10

Authors

Dokurno, P.,Surgenor, A.E.,Shaw, T.,Macias, A.T.,Massey, A.J.,Williamson, D.S. (deposition date: 2010-01-13, release date: 2011-01-26, Last modification date: 2024-02-21)

• Primary citation: Macias, A.T.,Williamson, D.S.,Allen, N.,Borgognoni, J.,Clay, A.,Daniels, Z.,Dokurno, P.,Drysdale, M.J.,Francis, G.L.,Graham, C.J.,Howes, R.,Matassova, N.,Murray, J.B.,Parsons, R.,Shaw, T.,Surgenor, A.E.,Terry, L.,Wang, Y.,Wood, M.,Massey, A.J.; Adenosine-Derived Inhibitors of 78 kDa Glucose Regulated Protein (Grp78) ATPase: Insights into Isoform Selectivity.; J.Med.Chem., 54:4034-4041, 2011; PubMed: 21526763; DOI: 10.1021/jm101625x

Experimental method

X-RAY DIFFRACTION (1.95 Å)