3LDJ

Crystal structure of aprotinin in complex with sucrose octasulfate: unusual interactions and implication for heparin binding

Summary for 3LDJ

• Entry DOI: 10.2210/pdb3ldj/pdb
• Related: 3LDM
• Related PRD ID: PRD_900013
• Descriptor: Pancreatic trypsin inhibitor, 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, ACETATE ION, ... (4 entities in total)
• Functional Keywords: aprotinin, sucrose octasulfate, disulfide bond, protease inhibitor, secreted, serine protease inhibitor, hydrolase inhibitor
• Biological source: Bos taurus (bovine,cow,domestic cattle,domestic cow)
• Cellular location: Secreted: P00974
• Total number of polymer chains: 3
• Total formula weight: 20624.55

Authors

Yang, I.S.,Kim, T.G.,Park, B.S.,Kim, K.H. (deposition date: 2010-01-13, release date: 2010-09-15, Last modification date: 2020-07-29)

• Primary citation: Yang, I.S.,Kim, T.G.,Park, B.S.,Cho, K.J.,Lee, J.H.,Park, Y.,Kim, K.H.; Crystal structures of aprotinin and its complex with sucrose octasulfate reveal multiple modes of interactions with implications for heparin binding.; Biochem.Biophys.Res.Commun., 2010; PubMed: 20529698; DOI: 10.1016/j.bbrc.2010.05.113

Experimental method

X-RAY DIFFRACTION (1.7 Å)