3LBZ

Crystal Structure of the BCL6 BTB domain complexed with the small molecule inhibitor 79-6

Summary for 3LBZ

Entry DOI	10.2210/pdb3lbz/pdb
Descriptor	B-cell lymphoma 6 protein, N-[(4-bromophenyl)sulfonyl]acetamide, (2R)-2-[(5Z)-5-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanedioic acid, ... (4 entities in total)
Functional Keywords	transcription regulation, transcription
Biological source	Homo sapiens (human)
Cellular location	Nucleus (By similarity): P41182
Total number of polymer chains	2
Total formula weight	31047.72
Authors	Ghetu, A.F.,Prive, G.G. (deposition date: 2010-01-08, release date: 2010-04-28, Last modification date: 2023-09-06)
Primary citation	Cerchietti, L.C.,Ghetu, A.F.,Zhu, X.,Da Silva, G.F.,Zhong, S.,Matthews, M.,Bunting, K.L.,Polo, J.M.,Fares, C.,Arrowsmith, C.H.,Yang, S.N.,Garcia, M.,Coop, A.,Mackerell, A.D.,Prive, G.G.,Melnick, A. A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo. Cancer Cell, 17:400-411, 2010 Cited by PubMed: 20385364 DOI: 10.1016/j.ccr.2009.12.050 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation