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3LBK

Structure of human MDM2 protein in complex with a small molecule inhibitor

Summary for 3LBK
Entry DOI10.2210/pdb3lbk/pdb
Related1YCR 3LBJ 3LBL
DescriptorE3 ubiquitin-protein ligase Mdm2, 6-chloro-3-[1-(4-chlorobenzyl)-4-phenyl-1H-imidazol-5-yl]-1H-indole-2-carboxylic acid, SULFATE ION, ... (4 entities in total)
Functional Keywordsmdmx, mdm2, p53, inhibitor, alternative splicing, cytoplasm, ligase, nucleus, phosphoprotein, proto-oncogene, ubl conjugation, ubl conjugation pathway, zinc-finger
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight11717.46
Authors
Popowicz, G.M.,Czarna, A.,Wolf, S.,Holak, T.A. (deposition date: 2010-01-08, release date: 2010-03-16, Last modification date: 2023-11-01)
Primary citationPopowicz, G.M.,Czarna, A.,Wolf, S.,Wang, K.,Wang, W.,Domling, A.,Holak, T.A.
Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery
Cell Cycle, 9:1104-1111, 2010
Cited by
PubMed: 20237429
DOI: 10.4161/cc.9.6.10956
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

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