3L9H
X-ray structure of mitotic kinesin-5 (KSP, KIF11, Eg5)in complex with the hexahydro-2H-pyrano[3,2-c]quinoline EMD 534085
Summary for 3L9H
Entry DOI | 10.2210/pdb3l9h/pdb |
Descriptor | Kinesin-like protein KIF11, ADENOSINE-5'-DIPHOSPHATE, 1-[2-(dimethylamino)ethyl]-3-{[(2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl]methyl}urea, ... (4 entities in total) |
Functional Keywords | mitotic spindle kinesin, eg5, small molecule inhibitor, emd 534085, acetylation, atp-binding, cell cycle, cell division, coiled coil, microtubule, mitosis, motor protein, nucleotide-binding, phosphoprotein, polymorphism |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P52732 |
Total number of polymer chains | 2 |
Total formula weight | 83918.63 |
Authors | Knoechel, T. (deposition date: 2010-01-05, release date: 2010-03-02, Last modification date: 2024-03-20) |
Primary citation | Schiemann, K.,Finsinger, D.,Zenke, F.,Amendt, C.,Knochel, T.,Bruge, D.,Buchstaller, H.P.,Emde, U.,Stahle, W.,Anzali, S. The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5. Bioorg.Med.Chem.Lett., 20:1491-1495, 2010 Cited by PubMed: 20149654DOI: 10.1016/j.bmcl.2010.01.110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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