3KXZ

The complex crystal structure of LCK with a probe molecule w259

Summary for 3KXZ

Entry DOI	10.2210/pdb3kxz/pdb
Descriptor	Proto-oncogene tyrosine-protein kinase LCK, SULFATE ION, CALCIUM ION, ... (5 entities in total)
Functional Keywords	lck, acetylation, atp-binding, cell membrane, chromosomal rearrangement, cytoplasm, disease mutation, host-virus interaction, kinase, lipoprotein, membrane, myristate, nucleotide-binding, palmitate, phosphoprotein, polymorphism, proto-oncogene, transferase, tyrosine-protein kinase, structural genomics, protein structure factory, psf
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P06239
Total number of polymer chains	1
Total formula weight	33846.46
Authors	Xu, Z.B.,Moy, F.J.,Kelleher, K.,Mosyak, L.,Protein Structure Factory (PSF) (deposition date: 2009-12-04, release date: 2010-06-23, Last modification date: 2011-07-13)
Primary citation	Moy, F.J.,Lee, A.,Gavrin, L.K.,Xu, Z.B.,Sievers, A.,Kieras, E.,Stochaj, W.,Mosyak, L.,McKew, J.,Tsao, D.H. Novel synthesis and structural characterization of a high-affinity paramagnetic kinase probe for the identification of non-ATP site binders by nuclear magnetic resonance. J.Med.Chem., 53:1238-1249, 2010 Cited by PubMed: 20038108 DOI: 10.1021/jm901525b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.37 Å)

Structure validation