3KVZ

Structural basis of the activity and substrate specificity of the fluoroacetyl-CoA thiesterase FlK - wild type FlK in complex with FAcCPan

Summary for 3KVZ

Entry DOI	10.2210/pdb3kvz/pdb
Related	3KUV 3KUW 3KV7 3KV8 3KVI 3KVU 3KW1 3KX7 3KX8
Descriptor	Fluoroacetyl-CoA thioesterase FlK, (2R)-N-{3-[(5-fluoro-4-oxopentyl)amino]-3-oxopropyl}-2,4-dihydroxy-3,3-dimethylbutanamide (3 entities in total)
Functional Keywords	fluoroacetyl-coa thioesterase flk, thioesterase, hot-dog folding, hydrolase
Biological source	Streptomyces cattleya
Total number of polymer chains	8
Total formula weight	122876.20
Authors	Dias, M.V.B.,Huang, F.,Chirgadze, D.Y.,Tosin, M.,Spiteller, D.,Valentine, E.F.,Leadlay, P.F.,Spencer, J.B.,Blundell, T.L. (deposition date: 2009-11-30, release date: 2010-04-28, Last modification date: 2023-09-06)
Primary citation	Dias, M.V.,Huang, F.,Chirgadze, D.Y.,Tosin, M.,Spiteller, D.,Dry, E.F.,Leadlay, P.F.,Spencer, J.B.,Blundell, T.L. Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK. J.Biol.Chem., 285:22495-22504, 2010 Cited by PubMed: 20430898 DOI: 10.1074/jbc.M110.107177 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation